Yoshiki Ohshima graduated from the Tokyo Institute of Technology in 1994 with a bachelor's degree. In 1996, he received a master's degree in Information Science on the design and implementation of a programming language with transactional facility from the same institution. He was awarded his PhD for the creation of "Kedama", a massively parallel particle programming system, from the Tokyo Institute of Technology in 2006.

In 2000, he joined Walt Disney Imagineering R&D, first as an intern and then as a full-time technical staff member. He worked on theme park related research projects as well as end-user computer environments. In 2002, he joined Twin Sun, Inc. From 2007 he worked at the Viewpoints Research Institute.

At VPRI, Yoshiki worked on projects include bringing the etoys environment to children via the "XO" and the One Laptop Per Child (olpc) initiative, multilingualization of software environments, and the STEPS project. Currently, Yoshiki is a Principal Investigator at Human Advancement Research Community (HARC) Y Combinator Research.